Pharmacokinetics, pKa, dissolutions, EPAR, FDA - screening tools

  • FDA approval packages (alphabetical list of molecules; click on 'approval listing, letters, reviews...' and in the subsequent table click on 'reviews'.)
  • FDA Guidance for Industry to individual drug substances
  • EPAR European Public assessment Reports
  • Public Assessment Reports from National Procedures or MRP/DCP - only several countries provide them.
  • Drugs com - regular monographies of FDA approved medicines
  • SciFinder substance, chemistry, and related scientific information (login* - info K. Schneiderová)
  • BCS classification - TSRL Inc.
  • DrugBank - University of Alberta
  • Dissolution methods at FDA
  • Simple calculator for calculation of % of ionisation based at pKa and pH
  • Simple calculator of SD
  • Toxicology - database RTECS (Registry of Toxic Effects of Chemical Substances). Info about RTECS see here.
  • ChemIDPlus Lite - Chemical Information Resources pointing to biomedical information.
  • Wilson and Gisvold's textbook of organic medicinal and pharmaceutical chemistry
  • Cell Signaling Pathfinder - intracellular signalling pathways